Video posted online showed orange-clad rescue workers clambering over mounds of rubble. It was not clear how tall the building had been before it collapsed, but there appeared to be commercial properties at street level.
The building collapsed at about 7:30 p.m. (1130 GMT) and 34 people were rescued in the following two hours, the Quanzhou authorities said.
The Fujian provincial government said that as of Friday, the province had 296 cases of coronavirus and 10,819 people had been placed under observation after being classified as suspected close contacts.
No reason was given for the collapse of the hotel.